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TAMOXIFEN CITRATE (NOLVADEX)

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TAMOXIFEN CITRATE is a nonsteroidal agent that has demonstrated potent antiestrogenic effects related to its ability to compete with estrogen for binding sites in target tissues. Tamoxifen citrate is an oral anti-estrogen and estrogen antagonist which competes with estrogen at the receptor sites reducing estrogenic expression. Tamoxifen citrate is a Selective Estrogen Receptor Modular (SERM) acting via estrogen site competition as opposed to Aromatase Inhibitor (AI) drugs which prevent aromatase derived estrogens from being created.

CAS Number: 54965-24-1
Molecular Formula: C32H37NO8

Category:

Description

TAMOXIFEN CITRATE (NOLVADEX)

Manufacturer: Hilma Biocare
Pack: 50 tabs/bottle ( 20 mg/tab )
Drug class: Estrogen-Agonist/Antagonist
Common names : Nolvadex, Nolva, Tamoxifen, Zymoplex, Soltamox, Nolvaxyl, Tamoximed, Tamodex, Cytotam, Mamofen, Xyfen, Tamox, Kessar, Tomifen, Tevafen, Oncotam, Oncomox, Neotam, Valodex, Caditam
Chemical structure: 2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine

Info: Tamoxifen Citrate is a Selective Estrogen Receptor Modulator (SERM) that was created in 1961 by ICI now known as AstraZenaca. Often referred to as an anti-estrogen, Tamoxifen Citrate is actually both an antagonist and agonist. This means it will act as an anti-estrogen in certain areas of the body while acting as an estrogen in other areas.

Tamoxifen Citrate has been used medically for decades and has been highly successful in breast cancer treatment, specifically hormone-responsive breast cancer. It is also a medication that is used by many anabolic steroid users, but it is not a steroid. This is a drug steroid users will sometimes use during steroid use to help with estrogenic related side effects brought on by specific steroids. However, it is most commonly used during Post Cycle Therapy (PCT).

TAMOXIFEN CITRATE PROFILE

  • Anabolic components: N/a
  • Androgenic component: N/a
  • Water Retention: No
  • High Blood Pressure: Unlikely
  • Aromatization: Estrogen antagonist (does not prevent aromatization process)
  • Liver Toxic: Very low
  • Half-life 5-7 days (some reports as long as 14 days)

EFFECTS

Tamoxifen Citrate will bind to the receptors in the chest preventing the estrogen from binding.

It is also not enough gynecomastia protection for all men, but that depends on how high estrogen levels go as well as genetics. If more or stronger protection is needed Aromatase Inhibitors (AI’s) are recommended. AI’s are anti-estrogens that inhibit aromatase activity and lower serum estrogen levels.

Also we have the testosterone stimulating effects of Tamoxifen Citrate.

Research conducted at the end of the 70s in University of Ghent in Belgium show the benefits of Tamoxifen Citrate (Nolvadex) over Clomiphene Citrate (Clomid) to increase testosterone levels.

If prior low levels existed, Tamoxifen Citrate won’t magically fix this. If severe damage was done to the HPTA you will not recover and may be in need of low testosterone treatment.

DOSE RANGE AND DURATION OF USE

Tamoxifen citrate therapy should last at minimum 4 to 6 weeks
Average Mild Dosage: 10-20mg/daily
Average Dosage: 10-40mg/daily
Women: 5-10mg/daily

SIDE EFFECTS

Hot Flashes
Upset Stomach
Headaches
Vaginal Itching, bleeding, discharge or discomfort

Here is more side effects of Tamoxifen Citrate but less common:
Rash
Decreased White Blood Cell Count
Endometrial Changes
Increased Triglyceride Levels
Pulmonary Embolism

Important Note: Women who are pregnant or who may become pregnant should not use Tamoxifen Citrate or any SERM as use will potentially damage the developing child and with strong probability.

STORAGE

To be store in a dry place protected from light, at a temperature of 15-25 ° C. Keep out of reach of children.

MIX/COMBINE YOUR STEROIDS CYCLE

For a proper PCT it will often include another SERM Clomiphene Citrate (Clomid).

It is also stacked with Proviron for a stronger anti-estrogenic effect.

 

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